The wing staff functions include the director of staff, 5th Comptroller Squadron, History, Legal, Chaplain, Safety, Command Post, Arms Control, Inspector General, Equal Opportunity, Public Affairs, Protocol, Community Action Board, Information Protection, Personnel Reliability Program and the Sexual Assault Response Coordinator.

The 5th Operations Group is the backbone of the 5th Bomb Wing, providing the aircrews who fly the wing's B-52H Stratofortress aircraft. The 5th OG is comprised of the 23rd Bomb Squadron, 69th Bomb Squadron and the 5th Operations Support Squadron.

The 5th Maintenance Group supports the dynamic operations of both the 5th Bomb Wing and 91st Missile Wing. It provides on- and off-equipment maintenance on B-52H Stratofortresses, and special support on Minuteman III missiles and UH-1N helicopters. The group also provides munitions, aircraft maintenance and maintenance operations support. Squadrons assigned to the 5th MG are the 5th Munitions Squadron, 5th Maintenance Squadron, 5th Maintenance Ops Squadron and 5th Aircraft Maintenance Squadron.

The 5th Mission Support Group is committed to providing flawless mission support. Focused on delivering essential installation mission support and community service, securing our resources, providing proper care of base facilities and infrastructure, while developing combat-ready airmen. The group's 1,600 military and civilian members serve the 5th Bomb Wing, 91st Missile Wing and other assigned tenant units -- approximately 12,000 people. The 5th MSG consist of the 5th Civil Engineer Squadron, 5th Communications Squadron, 5th Force Support Squadron, 5th Security Forces Squadron, 5th Contracting Squadron and 5th Logistics Readiness Squadron.

The 5th Medical Group offers outpatient services including aerospace medicine, dental, family medicine, medical nutrition therapy, mental health, optometry, pain management, pediatrics, physical therapy, and women's health. The group consists of the 5th Medical Operations Squadron and 5th Medical Support Squadron.